IPF1/PDX1 deficiency andβ-cell dysfunction in psammomyus obesus, an animal with type 2 diabetes

摘要

The homeodomain transcription factor IPF1/PDX1 is required inβ-cells for efficient expression of insulin, glucose transporter 2, and prohormone convertases 1/3 and 2. Psammomyus obesus, a model of diet-responsive type 2 diabetes, shows markedly depleted insulin stores when given a high-energy(HE)diet. Despite hyper- glycemia, insulin mRNA levels initially remained un- changed and then decreased gradually to 15/100 of the basal level by 3 weeks.