Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model

摘要

The KK/Ta mouse strain serves as a suitable polygenic model for human type 2 diabetes. Using 93 microsatel- lite markers in 208 KK/Ta ×(BALB/c×KK/Ta)F1 male backcross mice, we carried out a genome-wide linkage analysis of KK/Ta alleles contributing to type 2 diabetes and related phenotypes, such as obesity and dyslipide- mia. We identified three major chromosomal intervals significantly contributing to impaired glucose metabo- lism: one quantitative trait locus for impaired glucose tolerance on chromosome 6 and two loci for fasting blood glucose levels on chromosomes 12 and 15.