Hydrogen Sulfide Therapy in Diabetes- Accelerated Atherosclerosis: A Whiff of Success

摘要

Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in diabetes. Atherosclerosis occurs earlier and with greater severity in the population with diabetes, leading to a much higher risk of myocardial infarction, stroke, and limb ischemia and amputation. Although numerous factors contribute to the etiology of atherosclerosis, oxidative stress and inflammation play a fundamental role and both processes are exacerbated in diabetes. Given the rapidly growing worldwide incidence of diabetes, there is a critical need for new therapies that target atherogenesis and its clinical manifestations in patients with diabetes.