Association of vitamin D receptor polymorphisms with metabolic syndrome-related components: A cross-sectional study

摘要

Background The association between vitamin D receptor ( VDR ) polymorphisms and metabolic syndrome (MS) has been demonstrated by epidemiological studies while their correlation remain controversial. The aim of this study is to investigate the association of VDR gene polymorphisms with MS and MS-related components in the two communities of Hangzhou. Methods A total of 394 subjects were enrolled in the cross-sectional study. Four VDR gene polymorphisms ( Apa I, Bsm I, Fok I, and Taq I) were selected based on human genome sequence databases and genotyped using the MassARRAY Analyzer Compact. Results In lipid profile, the TT genotype of Apa I had a significantly lower risk of hypertriglyceridemia compared with the GG+GT genotypes (recessive model: OR?=?0.141; 95% CI?=?0.041–0.486; p ?0.01) and the GG genotype (codominant model: OR?=?0.155; 95% CI?=?0.044–0.545; p ?0.01). The levels of triglyceride (TG) in the TT genotype of Apa I were lower than the GG+GT genotypes (1.29?±?0.63 vs. 1.78?±?1.59?mmol/L, p ?0.01). Furthermore, the AA+GA carriers of Bsm I had lower levels of high-density lipoprotein cholesterol (HDL-C) than the GG carriers (1.28?±?0.29 vs. 1.42?±?0.34?mmol/L, p ?0.05). The CC+TC carriers of Taq I also suffered from lower HDL-C compared with the TT carriers (1.27?±?0.29 vs. 1.42?±?0.34?mmol/L, p ?0.01). For arterial blood pressure, the CC carriers had lower systolic blood pressure (SBP) than the TT+TC carriers ( p ?0.01) and the TT carriers of Fok I ( p ?0.05). However, the Fok I polymorphisms were not associated with SBP and the mean blood pressure of both groups laid within the normal range. Conclusions In our study, VDR polymorphisms show no association with the MS risk. The present results suggest that the VDR Apa I polymorphism is associated with hypertriglyceridemia and predisposed to developing MS, while the variants of Bsm I and Taq I seem to affect HDL-C. Nevertheless, the effect of Fok I variants with SBP is ambiguous.