Lesson of the month: Severe leukoencephalopathy by SARS-CoV-2

摘要

Neurological manifestations associated with SARS-CoV-2 infection as well as its pathogenesis are insufficiently explained. We present two cases of severe COVID-19 who required hospitalisation in the intensive care unit with persistently depressed mental status and severe leukoencephalopathy. We discuss the clinical and radiological findings and also propose the possible pathogenesis involved.? Royal College of Physicians 2021. All rights reserved.