Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19

摘要

Objectives Previous observational studies have suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients. Methods Several cardiac markers were analysed in this meta-analysis. RevMan 5.4 was used to provide pooled estimates for standardised mean difference (SMD) with 95% confidence intervals. Results Twenty-nine clinical studies were included in this meta-analysis. Significantly higher CK-MB (0.64, 95% CI?=?0.19–1.09), PCT (0.47, 95% CI?=?0.26?0.68), NT-proBNP (1.90, 95% CI?=?1.63–2.17), BNP (1.86, 95% CI?=?1.63?2.09), and d -dimer (1.30, 95% CI?=?0.91?1.69) were found in severe compared with non-severe COVID-19. Significantly higher CK-MB (3.84, 95% CI?=?0.62?7.05), PCT (1.49, 95% CI?=?0.86?2.13), NT-proBNP (4.66, 95% CI?=?2.42?6.91), BNP (1.96, 95% CI?=?0.78?3.14), troponin (1.64 (95% CI?=?0.83?2.45), and d -dimer (2.72, 95% CI?=?2.14?3.29) were found in those who died from compared with survivors of COVID-19. Conclusions High CK-MB, PCT, NT-proBNP, BNP, and d -dimer could be predictive markers for severity of COVID-19, while high CK-MB, PCT, NT-proBNP, BNP, troponin, and d -dimer could be predictive markers for survival of COVID-19 patients.