A Study of Serum Magnesium and Serum Zinc Concentration In Type 2 Diabetes Mellitus Patients with and without Diabetic Nephropathy

摘要

Background : The deficiency of important trace elements like Magnesium and Zinc in terms of their serum concentrations in Type 2 Diabetes Mellitus patients, commonly claimed to be a cause of diabetic nephropathy. So the measurement of these two important trace elements in diabetic patients and their replenishment in deficient state could be a possible deterrent to the progression of diabetic nephropathy. Materials and Methods : This study was undertaken at Silchar Medical College and Hospital, Silchar, from June 2018 to May 2019. A total of 100 patients were taken and divided into two study groups after satisfying the inclusion and exclusion criteria. Then the patients in each group were subjected test for estimation of zinc and magnesium concentration in serum. Results : Decrease in Zinc level was seen in all Type 2 diabetic patients, but the decrease was more in the group with diabetic nephropathy (62.96±25.48 μg/dl versus 106.06±27.94 μg/dl). Also decrease in magnesium was more significant in the group of patients with diabetic nephropathy (1.75±0.38 mg/dl versus 2.07±0.18 mg/dl). Conclusion : From this study it is evident that diabetic nephropathy is associated with lower serum zinc and magnesium level. There is a scope to study the impact of its replenishment to prevent diabetic nephropathy.