Galactose-deficient IgA1 and nephritis-associated plasmin receptors as markers for IgA-dominant infection-related glomerulonephritis

摘要

IgAnephropathy (IgAN) is the mostcommon formof glomerulonephritis worldwide. [1] Galactose-deficient IgA1 (Gd-IgA1) is known to deposit specifically in the glomeruli of patients with IgAN. [2] However, histologicalfeatures ofIgAN is variousas known in the Oxford Classification, which includes findings on lightmicroscopy such as, mesangial hypercellularity,endocapillary hypercellularity, segmental glomerulosclerosis, tubular atrophy/interstitialfibrosis,and crescents. In addition, it is well documented thatsecondary IgAN is induced by variousconditions, such as gastrointestinal disease, liver disorder,autoimmune disorders,and infection. [3] Among secondary IgAN, infection-related glomerulonephritis (IRGN)associated especiallywith staphylococcus species, induces glomerulonephritis dueto theformation ofIgA-dominant immunocomplex deposits. However, it remains unclear whether thereisan association between IgA-dominant IRGN and Gd-IgA1.