Evaluation of perfusion changes using a 2D Parametric Parenchymal Blood Flow technique with automated vessel suppression following partial spleen embolization in patients with hypersplenism and portal hypertension

摘要

Hypersplenismis defined by increased pooling and destruction ofthecorpuscular blood elements by an enlarged spleen. [1] It occurs in liver cirrhosis with portal hypertension, hematologic or immunologic disorders (eg, idiopathicthrombocytopenic purpura,autoimmune thrombocytopenia, systemiclupuserythematodes) or splenic malignancies (lymphoma or leukemia). [1–3] Clinicalsignsaresplenomegaly, thrombocytopenia, bi- or pancytopenia with corresponding symptoms including abdominal discomfort, pain, respiratory distress orearly satiety. [1] Splenectomy isa known effectivetreatment for hypersplenism. Nonetheless, splenectomy is frequently accompanied with severecomplications (approximately 10%), forexample, splenicabscess, septicemia, or unremitting bronchopneumonia dueto induced immunosuppression. [1] Furthermore, patients with severe(pan-)cytopeniaand comorbidities,especially cardiovascular diseases, may not beeligiblefor surgical splenectomy oreven completespleen embolization. [1,4] Therefore, theconcept of partialspleen embolization (PSE) was introduced.