A NOVEL AND EFFICIENT METHOD TO SYNTHESIS MICONAZOLE ANALOGUE AND ITS INTERMEDIATES

摘要

An alternative method for the preparation of Micanozole intermediate 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1- yl)ethanolis described, process involves the 2,4-Dichlorocaetophenone as the key raw material from which the substituted 2-chloro-1-(2,4-dichlorophenyl)ethanone was prepared.2-chloro-1-(2,4-dichlorophenyl)ethanone was reduced to 2-Chloro-1-(2,4-dichlorophenyl)ethanol and via SN 2 reaction with imidazoles the 1-(2,4-dichlorophenyl)- 2-(1H-imidazol-1-yl)ethanol was obtained, further1-(2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl0-1Himidazole was synthesized.