POINT OF CARE TESTING FOR CAPILLARY CREATININE CONCENTRATION IN PREGNANT WOMEN AT LOW AND HIGH RISK FOR PREGNANCY-RELATED ACUTE KIDNEY INJURY

摘要

Introduction: Pregnancy related acute kidney injury (PR-AKI) is associated with increased morbidity and mortality. Diagnosis remains challenging due to gestational physiological adaptations affecting serum creatinine and a lack of definitions validated perinatally. Point of care testing (PoCT) for creatinine has potential to enhance identification and triaging of women at risk of PR-AKI, and may in turn improve prevention, diagnosis and timely treatment. Before implementing creatinine PoCT within maternity care, accuracy must be established in both low-and high-risk pregnant women. This study aimed to i) perform a validation study of PoCT for capillary creatinine using the StatSensor Xpress Creatinine analyser (Nova Biomedical) across all gestations in low-risk women with normal renal function ii) to develop a model to improve PoCT accuracy in low risk women and to test the model in a second cohort of women with PR-AKI risk factors.