Effects of Different Doses of Dexmedetomidine on Intraocular Pressure after Suxamethonium in Non-ocular Surgeries: A Randomised Controlled Trial

摘要

Succinylcholine causes a rise in Intraocular Pressure (IOP) and is deleterious in patients with open globe injuries.Dexmedetomidine, by its virtue of central sympatholytic action can help prevent this rise in IOP.Aim: To find out the optimal dose of Dexmedetomidine in preventing the rise of IOP after administration of Suxamethonium.Materials and Methods: One hundred American Society of Anesthesiologists (ASA) I or II patients posted for non-ophthalmic surgery were included in this randomised, prospective, double blind study.Patients were randomly allocated to four groups.Group A (n=25) received Dexmedetomidine 0.6 μg/kg, Group B (n=25) received Dexmedetomidine 0.8 μg/kg, Group C (n=25) received Dexmedetomidine 1 μg/kg, Group D (n=25) received Normal Saline (NS) over a period of 10 minutes and IOP was measured at different points in time.Results: Premedication with Dexmedetomidine at doses of 0.6 μg/kg, 0.8 μg/kg and 1 μg/kg intravenous (IV) were equally effective in attenuation of the rise in IOP associated with Succinylcholine administration.The IOP recorded was 15.53±1.10 mm of Hg in Group A, 14.49±0.94 mm of Hg in Group B, 14.72±1.03 mm of Hg in Group C as compared to 20.12±1.40 mm of Hg in the control group (Group D) after 60 seconds of injecting Suxamethonium.It also significantly obtunded the sympathetic response to laryngoscopy and intubation.However, the incidence of side effects increased with incremental doses.Conclusion: Dexmedetomidine 0.6 μg/kg IV premedication is the optimum dose to be used for attenuating the rise in IOP associated with Succinylcholine administration in situations where rise of IOP may be detrimental.