Synthesis and Antiepileptic Activity Evaluation of Valproic Acid Derivatives by Niche Chemistry

摘要

In order to prepare new antiepileptic drugs with a broader clinical application and lower toxic side effects, we have employed esterification and condensation reactions (we call it Niche Chemistry) to reduce the use of valproic acid as the target molecule. In combination with the study of a broad‐spectrum of novel anticonvulsants, we have synthesized two valeric acid derivative compounds [(4‐acetamidophenyl 2‐propylvalerate (1), and (E)‐5‐(4‐((2‐propylpentanoyl)oxy)styryl)‐1,3‐phenylene bis(2‐propylvalerate) (2) by an esterification reaction. The maximum shock seizure test for products 1 and 2 has been successfully carried out, and their cytotoxic activity and survival effects have also been carefully investigated.