Case summary A 6-year-old castrated male domestic shorthair cat presented for lethargy and gastrointestinal signs after possible exposure to Nerium oleander leaves. The cat developed a ventricular arrhythmia that responded positively to the administration of digoxin-specific antibody fragments. Underlying hypertrophic cardiomyopathy was also diagnosed after the development of congestive heart failure. Humane euthanasia was elected owing to a lack of significant response to continued therapy. Relevance and novel information To our knowledge, this is the first report to describe the use of digoxin-specific antibody fragments in a cat. Nerium oleander toxicosis is associated with significant morbidity and mortality, and digoxin-specific antibody fragments have been used effectively in humans and animals. The development of cardiac necrosis may have contributed to worsening arrhythmias and highlights the importance of early intervention. The use of digoxin-specific antibody fragments for suspected N oleander toxicosis in a cat resulted in a rapid response and appeared to be well tolerated.
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机译：案例摘要一名6岁的阉割男性Shorthair猫在可能的暴露于腔内夹竹桃叶后呈现出嗜睡和胃肠道。该猫开发了一种心间心律失常，其对施用高氧素特异性抗体片段的施用响应。在充血性心力衰竭的发展之后也诊断出潜在的肥厚性心肌病。 Humane euthanasia was elected owing to a lack of significant response to continued therapy.与我们的知识相关性和新颖的信息，这是第一个描述在猫中使用Digoxin特异性抗体片段的报告。甲烯醇含有毒肠功能与显着的发病率和死亡率有关，并且在人类和动物中有效地使用了尖峰特异性抗体片段。心脏坏死的发展可能有助于恶化的心律失常，并强调早期干预的重要性。在猫中使用Digoxin特异性抗体片段用于疑似N渗肠毒性，导致快速反应，似乎是良好的耐受性。
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