The present study was aimed to explore the antihyperlipidemic and anti-inflammatory effect of acyclic isoprenoid on high fat diet fed rats. Hypercholesterolemia was induced by the diet comprising of the normal rat chow 84.3%, lard 5%, yolk powder 10%, cholesterol 0.2% and 0.5% bile salt were fed to the rats for the period of 8?weeks. The results showed that abnormally elevated levels of plasma lipid profiles. Three different doses of acyclic isoprenoid (20, 40 and 80?mg/kg b.w/day) were administered orally to hypercholesterolemia suffering rats for the period of 30?days. Among these three doses of acyclic isoprenoid, the dose 80?mg/kg b.w. was significantly decreased the plasma lipid profiles when compared to other two doses. The effect produced by acyclic isoprenoid (80?mg/kg b.w) was comparable to that of simvastatin. Therefore, 80?mg/kg b.w was fixed as a effective dose and used for further analyses. Acyclic isoprenoid administration reinstated the elevated levels of cardiac and inflammatory markers in both blood and serum of hypercholesterolemic rats. In addition, acyclic isoprenoid administration decreased activity of 3-hydroxy 3-methyl-glutaryl-CoA reductase and increased the activity of lecithin cholesterol acyl transferase. These findings suggest that the administration of acyclic isoprenoid was potentially ameliorated the cardiac marker enzymes and inflammatory markers in addition to its antihypercholesterolemic effect.
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机译：本研究旨在探讨无循环异戊二酚对高脂饮食喂养大鼠的抗医生和抗炎作用。通过饮食诱导高胆固醇血症，所述饮食包括正常大鼠周114.3％，猪油5％，蛋黄粉10％，胆固醇0.2％和0.5％胆汁盐为大鼠喂食8？周。结果表明，血浆脂质型材水平异常升高。将三种不同剂量的无环异戊二烯（20,40和80×mg / kg B.W / Day）口服给予高胆固醇血症的大鼠30？天。在这三剂的无循环异戊二烯中，剂量80？Mg / kg B.W.与其他两剂量相比，血浆脂质型材显着降低。无环异戊二烯（80×Mg / kg B.W）产生的效果与辛伐他汀的效果相当。因此，80？Mg / kg B.w固定为有效剂量并用于进一步分析。无环异戊二烯酮给药恢复了高胆固醇大鼠血液和血清中的心脏和炎症标志物的升高。此外，无环异戊二烯施用给药减少了3-羟基3-甲基 - 谷氨酸 - COA还原酶的活性，并增加了卵磷脂胆固醇酰基转移酶的活性。这些发现表明，除了其抗高血糖血糖效应外，无循环异戊二酚的给药潜在地改善了心脏标志物酶和炎症标志物。
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