Orai3 exacerbates apoptosis of lens epithelial cells by disrupting Ca 2+ homeostasis in diabetic cataract

摘要

Calcium participates in many important physiological processes. 1 Previous reports indicate that store depletion- operated Ca 2+ entry (SOCE) is one of the most common andubiquitouspathwaysforCa 2+ influx. 2 Oraifamilypro- teins localize at the plasma membrane to form a type of SOCE channel. The depletion of Ca 2+ stores evokes Ca 2+ influx via SOCE channel. 3 Three members of the Orai pro- tein (Orai1,2,3) display high selectivity for Ca 2+ . 4 Stromal- interacting molecule (STIM) family proteins, sensors of Ca 2+ depletion in the lumen of the endoplasmic reticulum (ER), rapidly translocate into ER–plasma membrane junc- tions to tether and activate Orai channels.