Synthesis of 2-trifluoromethylquinolines via copper-mediated intramolecular oxidative cyclization of N-(2-alkenylaryl) enamines

摘要

A general and efficient copper-mediated intramolecular oxidative cyclization of N -(2-alkenylaryl) enamines for the synthesis of 2-trifluoromethylquinolines has been developed. The targeted heterocycle is a privileged structure in many natural compounds and drugs with a broad range of biological activities.