Acute kidney injury and mortality in pediatric Lassa fever versus question of access to dialysis

摘要

Objectives To assess the prevalence of acute kidney injury (AKI), and its impact on outcome in hospitalized pediatric patients with Lassa fever (LF). Methods We reviewed the presenting clinical and laboratory features and outcomes of 40 successive hospitalized children with PCR-confirmed LF. The diagnosis and staging of AKI was based on KDIGO criteria. We compared groups of patients using t- or χ2 tests as necessary, and took p -values 0.05 as indicative of the presence of significant differences. Results Sixteen (40%) children had AKI. Case fatality rate (CFR) was 9/16 (56%) in children with and 1/24 (4%) in those without AKI (OR [95% CI] of CFR associated with AKI = 29.57 [3.17, 275.7]). Presentation with abnormal bleeding ( p = 0.008), encephalopathy ( p = 0.004), hematuria plus proteinuria ( p = 0.013), and elevated serum transaminase levels ( p 0.02) were significantly associated with an increased prevalence of AKI. Conclusion AKI prevalence in hospitalized pediatric patients with Lassa fever is high, and correlated with illness severity/CFR. The high prevalence underscores the need for access to hemodialysis, and clinical presentation and/or presence of hematuria plus proteinuria could serve as a ready prompt for referral for such specialized care.