Association of subclinical hypothyroidism with metabolic syndrome in females of reproductive age

摘要

Background and objective: The association of metabolic syndrome and subclinicalhypothyroidism is a matter of debate. Both confer an increased risk for cardiovasculardisease and type 2 diabetes mellitus, and previous studies showed overlap betweenfeatures of both conditions. This study aimed to evaluate the association of subclinicalhypothyroidism with metabolic syndrome in young women.Methods: This case control study was conducted in the internal medicine consultationdepartment of Rizgary Teaching Hospital Erbil, Iraq, from May 2017 to May 2018. Sixtyeight consecutive women with the metabolic syndrome as per the Harmonizing definitionwere compared to 95 age matched women with no metabolic syndrome as a control group.Detailed history and physical examination with blood pressure and waist circumferencesrecorded and appropriate fasting blood samples were tested for plasma glucose, lipidprofile, TSH, free T3, and free T4.Results: Subclinical hypothyroidism was present in 10 (14.7%) of the 68 women withmetabolic syndrome and four women (4.2%) of the 95 control group with a significantdifference (P = 0.018). Central obesity, hypertriglyceridemia, and low levels of high densitylipoprotein were present in 9 (17.3%), 9 (23.1%), and 10 (16.4%) women with subclinicalhypothyroidism with a significant difference for each association (P = 0.013, 0.001 and0.006, respectively).Conclusion: There is a significant association between subclinical hypothyroidism andmetabolic syndrome in young women.