Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research

摘要

Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for patients with acute lymphoblastic leukemia (ALL). Risk stratification of ALL varies across studies and generally includes a spectrum of demographic (e.g., age), clinical (e.g., white blood cell count, minimal residual disease, steroid sensitivity), phenotypic (B- versus T-cell origin), and cytogenetic characteristics. Several cytogenetic risk stratification schemes have been developed and are used as prognostic tools at diagnosis of ALL to guide treatment decisions. However, most prior studies focusing on the prognostic significance of cytogenetics in ALL were influenced by inclusion of patients with Philadelphia chromosome-positive (Ph+) B-ALL and defined for patients who received conventional chemotherapies.