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ALLOGENEIC CELL THERAPY OF ACUTE LYMPHOBLASTIC LEUKEMIA USING GENETICALLY ENGINEERED T CELLS TARGETING CD19
ALLOGENEIC CELL THERAPY OF ACUTE LYMPHOBLASTIC LEUKEMIA USING GENETICALLY ENGINEERED T CELLS TARGETING CD19
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机译:靶向CD19的转基因T细胞同种异体淋巴细胞白血病的同种异体细胞疗法
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摘要
Methods for treating a B cell malignancy comprising a population of genetically engineered immune cells (e.g., T cells), which express a chimeric antigen receptor (CAR) specific to CD19 and optionally an NK cell inhibitor (e.g., daratumumab). The genetically engineered immune cells may comprise a disrupted TRAC gene, a disrupted β2M gene, or both.
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