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Allelic polymorphisms of DNA repairing genes as markers of resistance to asbestos-containing aerosols

机译:DNA修复基因的等位基因多态性作为含石棉气溶胶的抗性标志物

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We studied the frequency distribution of DNA repairing genes allelic polymorphisms in the occupational group of asbestos-cement plants workers (n = 95). The aim of the work was to determine the probable molecular genetic markers of resistance to the development of bronchopulmonary pathology under the action of chrysotile-asbestos-containing dust. In 46 workers with chronic forms of bronchopulmonary pathology and 49 workers of the same professions without chronic diseases of the respiratory system, allelic polymorphisms XPD (rs13181, rs799793), ERCC1 (rs11615), XRCC3 (rs861539), XRCC1 (rs25487), ATM (rs664677), XRCC7 (rs7003908) and MLH1 (rs1799977) were determined using the real-time polymerase chain reaction. It was established that XRCC1?G/A (rs25487) (OR = 0.45; 95% CI: 0.18–1.10; P = 0.050; χsup2/sup = 3.73); MLH1?A/A (rs1799977) (OR = 0.28; 95% CI: 0.14 – 0.71; P = 0.003; χsup2/sup = 8.75) genotypes contribute to the resistance to bronchopulmonary pathology development, while XPD?Asn/Asn (rs799793) (OR = 2.20; 95% CI: 1.75–2.77; P = 0.001; χsup2/sup = 6.62); XRCC1?A/A (rs25487) (OR = 1.73; 95% CI: 1.23–2.43; P = 0.040; χsup2/sup = 3.92); ATM?T/T (rs664677) (OR = 3.47; 95% CI: 1.01–12.51; P = 0.020; χsup2/sup = 4.98); MLH1?A/G (rs1799977) (OR = 2.95; 95% CI: 1.17–7.49; P = 0.010; χsup2/sup = 6.42) genotypes were found to be associated with the risk of respiratory disease development. The obtained results show interconnection between certain alleles of DNA repair genes and the risk of bronchopulmonary pathology development under the influence of industrial aerosols, including asbestos-containing ones.
机译:我们研究了DNA修复基因的频率分布在职业基因石棉水泥工人职工(n = 95)中。该作品的目的是确定含甜于含甜硅酸盐的粉尘的作用下对支气管肺病理学的抗性的可能性分子遗传标记。在46名工人患有慢性肺肺病病理学的慢性形式,49名与呼吸系统的慢性疾病的相同行业,等位基因多态性XPD(RS13181,RS799793),ERCC1(RS11615),XRCC3(RS861539),XRCC1(RS25487),ATM(使用实时聚合酶链反应测定RS664677),XRCC7(RS7003908)和MLH1(RS1799977)。建立XRCC1?G / A(RS25487)(或= 0.45; 95%CI:0.18-1.10; P = 0.050;χ 2 = 3.73); mlh1?a / a(rs1799977)(或= 0.28; 95%ci:0.14 - 0.71; p = 0.003;χ 2 = 8.75)基因型有助于抗支气管肺病理学发育,而xpd? ASN / ASN(RS799793)(或= 2.20; 95%CI:1.75-2.77; P = 0.001;χ 2 = 6.62); XRCC1?A / A(RS25487)(或= 1.73; 95%CI:1.23-2.43; P = 0.040;χ 2 = 3.92); ATM?T / T(RS664677)(或= 3.47; 95%CI:1.01-12.51; P = 0.020;χ 2 = 4.98); mlh1?a / g(rs1799977)(或= 2.95; 95%ci:1.17-7.49; p = 0.010;χ 2 = 6.42)基因型与呼吸系统发育的风险有关。获得的结果显示了DNA修复基因的某些等位基因之间的互连以及在工业气溶胶的影响下,包括含石棉的影响,包括支气管肺病理学发展。

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