PREPARATION OF HYDRAZONE AND N-ACYLHYDRAZONE USING COMMERCIAL DRUGS AS REAGENTS: PRACTICAL CLASSES OF BIOACTIVE COMPOUND SYNTHESIS

摘要

Several scientific works demonstrate the chemical and medicinal importance of hydrazone compounds. In this regard, the present paper proposes some practical classes of chemoinformatics and organic chemistry, using investigative and illustrative strategies, to teach the synthesis of a hydrazone and a N-acylhydrazone with proven biological activity. The motivating element used for the development of this didactic material was the use of commercial drugs, such as hydralazine and isoniazid, as alternative reagents for the synthesis of the target compounds. The sequence of experimental classes was planned to demonstrate the role of chemistry in the development of new drugs, to estimulate the curiosity of undergraduate students and to facilitate learning and the assimilation of the contents.