Trade-off between local transmission and long-range dispersal drives infectious disease outbreak size in spatially structured populations

摘要

Transmission of infectious diseases between immobile hosts depends on the transmission characteristics of the infection and on the spatial distribution of hosts. Examples include infectious diseases of plants that are spread by wind or via vectors (e.g., Asiatic citrus canker spread between citrus trees), diseases that are transmitted between local host populations (e.g., sylvatic plague transmitted between rodents living in burrows), diseases of production animals that are spread between farms (e.g., avian influenza in poultry transmitted from farm to farm). We use spatial transmission modelling to investigate how the total number of infections over the course of an epidemic is determined by host clustering and spatial range of transmission. We find that for a given degree of clustering and infectivity of hosts, the number of infections is maximal if the spatial range of transmission is intermediate. In highly clustered populations we show that epidemic size can be approximated by a metapopulation model, illustrating that in such populations the transmission dynamics is dominated by transmission between clusters of hosts.