Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

摘要

An elegant paper by Yuan et al., recently published in Science,provides novel insights into the molecular features of neutralizingantibody responses to the severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2).1According to the principles of the “reverse vaccinology 2.0”postulated by Burton et al.,2 the authors explore the interactionsbetween potent neutralizing antibodies from naturally infecteddonors and their target epitopes, providing key information aboutstructural motifs and binding mode that may facilitate the designof vaccine antigens capable to elicit the immune response againstSARS-CoV-2. The vast majority of anti-CoV neutralizing antibodieshave been found to specifically target the receptor-bindingdomain (RBD) of the viral spike (S) protein, thus hindering SARSCoV-2binding to the host angiotensin converting enzyme 2(ACE2) receptor and viral entry.