Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

摘要

Representation of “reverse vaccinology 2.0” theory: focus on the molecular features of IGHV3-53-encoded antibodies. Monoclonal antibodies are obtained from seropositive subjects, isolated and structurally characterized. Based on the molecular features, a structure-based immunogen is designed and then tested in appropriate animal models