The anti-fatigue and anti-anoxia effects of Tremella extract

摘要

Objective The present study intended to explore the anti-fatigue and anti-hypoxia efficacy of Tremella extract in mouse model. Methods Kunming mice were randomized into 5 groups randomly (n?=?12/group; half male and female), and given 0.9%Nacl (10?mL/Kg Serving as blank control group)orally, 0.6?g/kg rhodiola capsule (Serving as positive group) and Tremella extract at doses of high (3.0?g/kg), middle (1.5?g/kg) and low (0.5?g/kg) once a day for 14?days. At the end of drug intragastric gavage, following endurance running test, rotating rod test, normobarie hypoxia test and sodium nitrite poisoning test were performed. Result 14-day Tremella extract administration fails to influence mouse horizontal and vertical movement indicating little neurotoxicity at chosen doses. Through rotating rod, forced running test, the anti-fatigue activity of Tremella extract was demonstrated. Via normobarie hypoxia test, sodium nitrite poisoning test, Tremella extract was confirmed to possess anti-hypoxia effect. Tremella extract treatment significantly enhanced the liver levels of superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), increased the expressions of ATP and hepatic glycogen, muscle glycogen in tissue. Conclusion We conclude that Tremella extract efficiently enhances mouse fatigue endurance and anti-hypoxia capability partly through energy reserves and antioxidant enzyme activity.