Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β1 Gene Expressions in Alcoholic Rats

摘要

Background and Objectives: Curcumin and exercise training are suggested to improve hepatic disorders. The aim of this study was to investigate effects of two weeks of swimming training and curcumin supplementation on platelet-derived growth factor (PDGF-BB) and transforming growth factor beta 1 (TGF-β1) gene expressions following ethanol consumption in Wistar male rats. Materials and Methods: Totally, 32 Wistar male rats were divided into four equal groups, including control, exercise, curcumin and curcumin-exercise groups. Ethanol was gavaged to all groups (g kgsup-1/sup) for four days. Then, the renunciation period (four days) started. The exercise period included two weeks, each week included five sessions of exhaustive swimming. Curcumin supplementation (50 mg kgsup-1/sup) was used with trainings. Results: Curcumin supplementation demonstrated significant decreases in expression of PDGF-BB ( P = 0.025) and TGF-β1 ( P = 0.033) genes. In exercise groups, significant decreases were seen in expression of PDGF-BB ( P = 0.007) and TGF-β1 ( P = 0.001) genes. Interaction of exercise and curcumin resulted in significant decreases in expression of PDGF-BB ( P = 0.040) and TGF-β1 ( P = 0.013) genes. Conclusions: In conclusion, expression decreases in PDGF-BB and TGF-β1 genes suggest that exercise and curcumin consumption can protect hepatic tissues through controlling hepatic satellite cell (HSC) activation, preventing negative effects of ethanol.