SUN-048 Endothelial STC1 prevents Lipopolysaccharide-induced actue kidney injury via TGF beta

摘要

Introduction: Lipopolysaccharide (LPS)-induced Epithelial injury plays acritical role in the pathogenesis of acute kidney injury (AKI). Stannio-calcin-1 (STC1), a pleiotropic glycoprotein, has been reported to protectischemic renal injury by reducing redox oxygen species, modulating in-flammatory release, and inhibiting cell apoptosis. However, regulators ofSTC1 expression as well as its physiologic function in kidneys were un-known. We sought to elucidate the relationship between TGF b and STC1in LPS-induced kidney injury in vitro and in vivo and to define thefunctional role of STC1 expression in renal tubular epithelium.