Early and Maximal Personalized Surgical Resection Improves Survival and Quality of Life in Low-grade Gliomas Patients

摘要

Diffuselow-grade glioma(LGG), i.e., WHO gradeII glioma, isa primary brain tumor which growsand migratesconstantlywithin thecentral nervous system,and which ultimately progress to high-grade glioma, resulting in neurologicalworsening and death. However, becausethese neoplasmsare very heterogeneous, it remains difficult to predict when the malignant transformationwill occurat theindividuallevel. Recently, Keshrietal. reported their preliminary experience with 130 LGGpatientsand observed that decreased overallsurvival(OS) wasassociated with age 50 years, tumor size 5cm, MIBindex 5%, Karnofksy performanceindex (KPS) score 70 and gemistocytic pathology.[1] Although this isa niceconfirmation ofthefact that older LGGpatients, with a poorclinicalstatus,a more voluminousand a moreaggressivetumor havea worse prognosis, severalresults need nonetheless to be moreextensively discussed.