Effect of physical fitness on colorectal tumor development in patients with familial adenomatous polyposis

摘要

Although accumulated epidemiological evidence indicates that a good physical fitness level may prevent the development of sporadic colorectal cancer (CRC), few studies have examined the effect of physical fitness level on familial adenomatous polyposis (FAP). This cross-sectional study aimed to examine the relationship between physical fitness and CRC development in patients with FAP. A total of 119 patients (54 male; 65 female) with FAP, aged 17 to 73 years, underwent a step test to induce exercise stress. Predicted maximal oxygen uptake (VO 2 max) was calculated for each patient by using heart rate as an index of physical fitness . The association of VO 2 max with the presence or absence of CRC and polyp diameter was examined. Patients with FAP were divided into 3 categories according to their VO 2 max (high, medium, and low). The association between maximum polyp size and VO 2 max among the patients with FAP without a history of colectomy was examined. The risk of CRC was significantly higher in the low VO 2 max group than in the high VO 2 max group (odds ratio = 4.07; 95% confidence interval, 1.02–16.26). The maximum polyp diameter was significantly negatively correlated with the VO 2 max among the patients with FAP without a history of colectomy ( r = ?.44, P = .01). In the multiple linear regression analysis, maximum polyp diameter was independently correlated with VO 2 max. Our results suggest a preventive association between physical fitness and CRC development or colorectal adenoma growth exists in patients with FAP.