Deep brain stimulation (DBS) can play a crucial role in the modulation of absence seizures, yet relevant biophysical mechanisms are not completely established. In this paper, on the basis of a biophysical mean-field model, we investigate a typical absence epilepsy activity by introducing slow kinetics of GABAB receptors on thalamus reticular nucleus (TRN). We find that the region of spike and slow-wave discharges (SWDs) can be reduced greatly when we add the DBS to TRN. Furthermore, we systematically explore how the corresponding stimulation parameters including frequency, amplitude and positive input duration suppress the SWDs under certain conditions. It is shown that the SWDs can be controlled as key stimulation parameters are suitably chosen. The results in this paper can be helpful for researchers to understand the thalamus stimulation in treating epilepsy patients, and provide theoretical basis for future experimental and clinical studies.
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机译：深脑刺激（DBS）可以在缺乏癫痫发作的调节中发挥至关重要的作用，但没有完全建立相关的生物物理机制。本文基于生物物理平均场模型，我们通过在丘脑网状核（TRN）上引入Gabab受体的慢动脉来研究典型的缺失癫痫活动。我们发现，当我们将DB添加到Trn时，可以大大减少尖峰和慢波放电（SWDS）的区域。此外，我们系统地探讨了包括频率，幅度和正输入持续时间的相应刺激参数如何在某些条件下抑制SWD。 It is shown that the SWDs can be controlled as key stimulation parameters are suitably chosen.本文的结果对于研究人员来说有助于了解丘脑治疗癫痫患者的刺激，并为未来的实验和临床研究提供理论依据。
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