STEADY SHEAR AND DYNAMIC SHEAR RHEOLOGICAL PROPERTIES OF CARBOXYMETHYL LOCUST BEAN GUM INFLUENCING EROSION OF THE POLYSACCHARIDE COAT OF COMPRESSION COATED TABLETS

摘要

Pulsatile drug delivery is one such system thereby delivering drug at the right time, right place and in right amounts and holds good promises and provides benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension, etc. The present study investigated that optimization of quinapril hydrochloride was successfully done and batch A8 was given satisfactory results. Tablets of quinapril hydrochloride were made by direct compression method. Microcrystalline cellulose was used as direct compressing agent. Sodium starch glycolate used as disintegrating agent and croscarmellose sodium used as super disintegrating agent. The resulting powder mixtures were then compressed into tablets using KBR machine. Dry coating using different concentrations of HPMCK4M, EC, and HPMCK100M. Also magnesium stearate and spray-dried lactose. Dry coated pulsatile tablet was prepared by placing 50% pulsatile release layer in 13 mm die and core tablet was placed on it. A1 to A 5 show less lag time, less in-vitro buoyancy study due to less concentration of polymer. Where A 7 gave drug release after 8 hours 97.6 ± 0.05%. This formulation can be considered for floating pulsatile delivery of quinapril hydrochloride.