Early nosocomial infection post-elective brain tumor surgery at a single South African neurosurgical center - a prospective cohort study

摘要

IntroductionIncurring a nosocomial infection post elective brain tumor surgery can be a devastating complication. Unfortunately, patient demographics, co-morbidities, nature of the neurosurgical procedures performed, and post-operative interventions in the Neurosurgical Intensive Care Unit, are all recognized independent risk factors.Materials and methodsWe performed a prospective study by consecutively enrolling 78 elective patients admitted to our hospital with neoplastic brain tumors, from the 01 July 2018 to the 31 March 2020, that were taken for operative resection. Data collected and analyzed in all 78 subjects included age, gender, HIV status, admission Glasgow Coma Score, admission CD4 count, pre-operative steroid treatment, in-hospital stay prior to surgery, pre-operative day CD4 count, operative day Glasgow Coma Score, time between prophylactic antibiotic administration and skin incision, craniotomy type, blood loss, duration of surgery, post-operative steroid therapy, day-7 post-operative nosocomial infection incidence, histological diagnosis, and total length of in-hospital patient stay.ResultsOur study results suggest that subjects over the age of 40-years, having an admission and/or pre-operative day absolute CD4 count?