Successful retrieval of oocytes from renal transplant recipient followed by surrogacy

摘要

Reproductive capacity is affected in women with end-stage renal disease by reducing the sexual desire andcausing abnormalities of hypothalamic–pituitary–ovarian axis. Renal transplantation is the treatment ofchoice for end-stage renal disease and it results in good recovery of reproductive function. But the renaltransplant patients are high-risk pregnant patients with life-threatening risk to mother, fetus, and graft.Pregnancy in these patients is challenging due to the risk of adverse maternal complications ofpreeclampsia, hypertension, gestational diabetes, urinary tract infections, teratogenic effects ofimmunosuppressive treatment, risk of deterioration of allograft function or acute rejection, and risk ofadverse fetal outcomes of premature birth, low birth weight, and small for gestational age infants. Hence,preconception counseling followed by surrogacy may be a better and safer option, especially if they havehypertension, proteinuria, graft dysfunction, and are taking potentially teratogenic drugs.