Comparison of the Effect of Voluven and Ringer Solution in Cardiopulmonary Bypass on the Bleeding After the Surgery and Renal Function in Coronary Artery Bypass Graft Surgeries

摘要

Background: This study compared the effect of Voluven and Ringer solution in cardiopulmonary bypass on the bleeding after the surgery and renal function in coronary artery bypass graft surgeries. Methods: Two types of prime solution including ringer - as Crystalloid- and Voluven were used in two groups and compared in terms of bleeding and renal function during the first 24 hours after the surgery in intensive care unit (ICU) cardiac surgery. Results: Amount of a 24-hour drainage was not statistically different (P 0.05). There was not any significant difference between groups regarding urinary output in two time periods, pump time and during the first 24 hours after the patient’s entry to ICU. The mean of partial thromboplastin time postop in experiment and control groups was significantly different (P 0.05). Plasma level of Bun-Cr , sodium, Potassium, hemoglobin, hematocrit, BT, PT and INR Platelets was not significantly different during the first 24 hours after the surgery (P 0.05). There was a significant difference between the two groups in terms of a need for blood transfusion during the surgery and first 24 hours after the surgery (Ringer 1.70 ± 0.9, Vovuven 1.07 ± 1.1) (P = 0.019). There was not a significant difference between two groups in terms of urinary protein secretion during the first 24 hours after the surgery (P = 0.08). Conclusions: It can be concluded that using Voluven as prime solution in comparison to lactate, in our study did not cause any significant difference in bleeding after the surgery and there was not so much need for blood injection in these patients.