NON-MONOAMINERGIC APPROACHES IN SEARCH OF NOVEL ANTIDEPRESSANTS

摘要

Depression is a common disabling mental illness which affects millions of people each year and impairs all aspects of everyday life (Murray and Lopez 1996). The burden of the disorder is progressively increasing and the World Health Organization has considered that it will become in the 2020 the second worldwide cause of disability with heavy economic burden for the we- stern societies (Lopez and Murray 1998).