Haemopoietic stem cell transplantation is a curative treatment option with minimal transplant-related complications for patients with severe Glanzmann's thrombasthenia

摘要

Glanzmann’s thrombasthenia is a rare autosomal recessivebleeding disorder of platelet function caused by a qualitative orquantitative defect of the platelet membrane glycoprotein IIb/IIIa.For patients with a severe form the condition haemopoietic stem celltransplantation (HSCT) is the only curative option. Since 1985 therehave been 19 allogeneic stem cell transplants reported in 18 patientswith Glanzmann’s thrombasthenia. We report two successful cases of patients with severeGlanzmann’s thrombasthenia with anti-platelet antibodies whohad a successful allogeneic HSCT in our centre.