Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve

摘要

This study proposes a 3D particle-based (discrete) multiphysics approach for modellingcalcification in the aortic valve. Different stages of calcification (from mild to severe) were simulated,and their effects on the cardiac output were assessed. The cardiac flow rate decreases with thelevel of calcification. In particular, there is a critical level of calcification below which the flow ratedecreases dramatically. Mechanical stress on the membrane is also calculated. The results show that,as calcification progresses, spots of high mechanical stress appear. Firstly, they concentrate in theregions connecting two leaflets; when severe calcification is reached, then they extend to the area atthe basis of the valve.