COVID-19 infection: mitohormetic concept of immune response

摘要

In the Editorial of a recent issue of Cell Death & Differentiation, the authors proposed that the immune response in COVID-19 has two phases: non-severe (immune protection) and severe (inflammation damaging)1 . They suggest using Vitamin B3 (nicotinamide and nicotinic acid) in the second phase. Unless we have a clearer understanding of the mechanism of Vitamin B3 anti-inflammatory activity, particularly in lung tissue, it is difficult to progress toward an evaluation of this solution.