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Mortality and complications after hip fracture among elderly patients undergoing hemodialysis

机译:血液透析患者髋关节骨折后的死亡率和并发症

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Background Osteoporotic hip fractures cause high mortality and morbidity in elderly adults. Compared to the general population, subjects with end-stage renal disease and hemodialysis often develop mineral bone disorders and have a higher risk for hip fractures. Methods We conducted a matched cohort study design and used competing risk analysis to estimate the cumulative incidence of the complication rate. Subjects aged greater than 60?years with hip fracture were selected from Taiwan’s National Health Insurance Research Database covering a period from 1997 to 2007, and these subjects were followed up until 2009. We used the Kaplan–Meier method to estimate the overall survival and used the log-rank test and multiple Cox proportional hazards model to explore the risk factors for survival. The cumulative incidence of the first complication was estimated using competing risk analysis. Results Among hemodialysis subjects, the three-month, one-year, two-year and five-year mortality rates were 17.3?%, 37.2?%, 51.5?%, and 80.5?%, respectively; the one-year and five-year cumulative incidences of the first surgical complication were 14.2?% and 20.6?%, respectively; and the three-month cumulative incidence of the first medical complication was 24.1?%. Hemodialysis subjects presented a 2.32 times (95?% CI: 2.16–2.49) higher hazard ratio of overall death, 1.15 times (95?% CI: 1.01–1.30) higher sub-hazard ratio (sub-HR) of surgical complications, and 1.35 times (95?% CI: 1.21–1.52) higher sub-HR of the first medical complication than non-hemodialysis controls. Conclusions The overall mortality and complication rates of hemodialysis subjects after surgery for hip fracture were significantly higher than those of non-hemodialysis subjects. Further prospective studies which include important risk factors are necessary to more precisely quantify the adjusted effect of hemodialysis.
机译:背景技术骨质疏松症骨折导致老年人死亡率和发病率高。与一般人群相比,患有末期肾病和血液透析的受试者经常发育矿物骨障碍,并且具有更高的髋部骨折风险。方法我们进行了匹配的队列研究设计,并使用竞争风险分析,以估算并发症率的累积发生率。从1997年至2007年的台湾全国医疗保险研究数据库中选择了大于60岁的受试者,从1997年到2007年占据了一段时间,而这些科目直到2009年。我们使用了Kaplan-Meier方法来估计整体生存和使用的方法日志秩检验和多氧化碳比例危险模型探讨生存的危险因素。利用竞争风险分析估计了第一并发症的累积发生率。血液透析科目的结果,三个月,一年,两年和五年死亡率分别为17.3?%,37.2?%,51.5?%和80.5?%;第一年和五年的五年累积发病率分别为14.2?%和20.6?%;第一次医疗复制的三个月累积发病率为24.1?%。血液透析受试者呈现2.32倍(95℃:2.16-2.49)危险比总死亡率较高,1.15倍(95〜1%:1.01-1.30)手术并发症的次危害比(Sub-Hr),和1.35次(95〜1%:1.21-1.52)第一种医学并发症的次高,而不是非血液透析控制。结论髋部骨折手术后血液透析受试者的总体死亡率和并发症率明显高于非血液透析受试者。进一步的前瞻性研究包括重要危险因素的进一步研究是更精确地量化血液透析的调整后的效果。

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