Effects of premedication with oral gabapentin on intraocular pressure changes following tracheal intubation in clinically normal dogs

摘要

Background Gabapentin is an antiepileptic drug widely approved as an add-on therapy for epilepsy treatment in human and dogs. There is a clinical impression that gabapentin is a suitable drug which attenuates the IOP elevation associated with tracheal intubation in humans. The present study performed to determine the effects of oral gabapentin on intraocular pressure (IOP) changes following tracheal intubation in dogs. Results Twenty adult healthy dogs were randomly assigned to treatment ( n =?10) and control ( n =?10) groups. Dogs in the treatment group received oral gabapentin (50?mg/kg) 2?h before induction of anesthesia and dogs in the control group received oral gelatin capsule placebo at the same time. The dogs were anesthetized with propofol 6?mg/kg, and anesthesia was maintained with a constant infusion of 0.2?mg/kg/min of propofol for 20?min. IOP were measured immediately before induction and then repeated immediately after induction, as well as 5?min, 10?min and 15?min following tracheal intubation in both groups. IOP was significantly higher immediately after induction, and 5?min after tracheal intubation when compared with IOP reading before induction in the control group. There was no statistically significant change in IOPs immediately after induction, and 5?min after tracheal intubation in comparison to the values before induction in the treatment group. Conclusions Based on the findings of this study, preanesthetic oral administration of gabapentin significantly prevents an increase in the IOP associated with tracheal intubation in dogs anesthetized with propofol.