NORMAL INTRAOCULAR PRESSURE GLAUCOMA MODEL AND EVALUATION METHOD OF PREVENTION OR THERAPEUTIC EFFECT FOR NORMAL INTRAOCULAR PRESSURE GLAUCOMA OF EVALUATION TARGET MEDICINE

摘要

To provide a glaucoma model being a useful model of the naturally-occurring normal intraocular pressure glaucoma, and an evaluation method of prevention or therapeutic effect for the normal intraocular pressure glaucoma of an evaluation target medicine, the method that is superior in clinical predictability.SOLUTION: A normal intraocular pressure glaucoma model comprises a non-human animal missing of ABCA1 genes. The model comprises the non-human animal missing of the present genes systemically or selectively in astrocyte/Muller cells. Also, an evaluation method of prevention or therapeutic effect for the normal intraocular pressure glaucoma of an evaluation target medicine comprises: a step of administering the evaluation target medicine to the normal intraocular pressure glaucoma model; and a step for evaluating that the evaluation target medicine has prevention or therapeutic effect for the normal intraocular pressure glaucoma, when an inhibitory effect to the detachment of retinal ganglion cells is significantly observed in comparison with the contrast administering a pharmacologically acceptable solvent instead of the evaluation target medicine, concerning the normal intraocular pressure glaucoma model after administering the evaluation target medicine.SELECTED DRAWING: Figure 2A