Detection of HER2 amplification in circulating free DNA in patients with breast cancer

K Page; N Hava; B Ward; J Brown; D S Guttery; C Ruangpratheep; K Blighe; A Sharma; R A Walker; R C Coombes; J A Shaw

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Detection of HER2 amplification in circulating free DNA in patients with breast cancer

机译：乳腺癌患者循环自由DNA中HER2扩增的检测

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Background:Human epidermal growth factor receptor 2 (HER2) is amplified and overexpressed in 20–25% of breast cancers. This study investigated circulating free DNA (cfDNA) for detection of HER2 gene amplification in patients with breast cancer.

机译：背景：将人表皮生长因子受体2（HER2）在20-25％的乳腺癌中被扩增和过表达。本研究研究了循环自由DNA（CFDNA）检测乳腺癌患者的HER2基因扩增。

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《British Journal of Cancer》 |2011年第8期|共7页
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K Page; N Hava; B Ward; J Brown; D S Guttery; C Ruangpratheep; K Blighe; A Sharma; R A Walker; R C Coombes; J A Shaw;
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中图分类肿瘤学;
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1. HER2 genomic amplification in circulating tumor DNA and estrogen receptor positivity predict primary resistance to trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer [J] . Hitomi Sakai, Junji Tsurutani, Tsutomu Iwasa, Breast cancer . 2018,第5期

机译：循环肿瘤DNA中的HER2基因组扩增和雌激素受体阳性预示着HER2阳性转移性乳腺癌患者对曲妥珠单抗Emtansine（T-DM1）的主要耐药性
2. Detection of ERBB2 (HER2) Gene Amplification Events in Cell-Free DNA and Response to Anti-HER2 Agents in a Large Asian Cancer Patient Cohort [J] . Jeeyun Lee, Aleksandra Franovic, Yukimasa Shiotsu, Frontiers in Oncology . 2019,第1期

机译：大型亚洲癌症患者队列中无细胞DNA中 ERBB2 （HER2）基因扩增事件的检测以及对抗HER2药物的反应
3. The combined blood analysis of cell-free DNA and genomic DNA of circulating tumor cells reveals additive value in hormone receptor-positive, HER2-negative metastatic breast cancer patients [J] . Intelligence: A Multidisciplinary Journal . 2020,第期

机译：循环肿瘤细胞的无细胞DNA和基因组DNA的组合血液分析揭示了激素受体阳性，HER2阴性转移性乳腺癌患者的添加剂值
4. Circulating Cell-Free DNA-Based qMSP Demonstrates That Sydecan2 Methylation as a Promising Epigenetic Biomarker for Early Detection of Patients with Precancerous and Cancerous Colorectal Lesions [C] . Sungwhan An, TaeJeong Oh, Dongjun Jeong, Molecular Medicine TRI-CON. . 2014

机译：循环无细胞的DNA基QMSP证明了Sydecan2甲基化作为有望的表观遗传生物标志物，用于早期检测患癌前和癌细胞病患者的患者
5. Hormonal exposures and breast cancer characterized by estrogen receptor and progesterone receptor status and Her2/neu oncogene amplification. [D] . Huang, Wen-Yi. 1998

机译：以雌激素受体和孕激素受体状态以及Her2 / neu癌基因扩增为特征的激素暴露和乳腺癌。
6. Detection of HER2 amplification in circulating free DNA in patients with breast cancer [O] . K Page, N Hava, B Ward, 2011

机译：乳腺癌患者循环游离DNA中HER2扩增的检测
7. Detection of HER2 amplification in circulating free DNA in patients with breast cancer [O] . Page, K, Hava, N, Ward, B, 2011

机译：乳腺癌患者循环游离DNA中HER2扩增的检测
8. Overcoming Resistance to Trastuzumab in HER2-Amplified Breast Cancers [R] . Moody, S. 2011

机译：克服HER2扩增乳腺癌对曲妥珠单抗的耐药性

Detection of HER2 amplification in circulating free DNA in patients with breast cancer

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