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Mortality among People Living with HIV and AIDS in China: Implications for Enhancing Linkage

机译:中国艾滋病毒/艾滋病患者的死亡率:对加强联系的启示

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To assess the patterns and predictors of AIDS-related mortality and identify its correlates among adult people living with HIV/AIDS (PLWHA) in China, a retrospective record-based cohort study was conducted among 18 years or older PLWHA, who had at least one follow up reported to the national database between January-1989 and June-2012. Cumulative Incidence Function was used to calculate AIDS-related mortality rate. Gray's test was used to determine the variation in cumulative incidence across strata. The Fine and Gray model was used to measure the burden of cumulative incidence of AIDS-related mortality and strength of its association with potential correlates. Among 375,629 patients, 107,634 died during study period, of which 54,759 (50.87%) deaths were AIDS-related. Cumulative mortality rates of AIDS-related death at one, two, five, 10 and 15 years post-diagnosis were 5.7%, 8.2%, 14.3%, 22.9% and 30.9%, respectively. Among PLWHA, male gender, ethnic minority and having AIDS were associated with significantly higher mortality. Further, homosexual transmission, being on ART and increasing CD4-testing frequency were associated with lower mortality. To reduce mortality among PLWHA, efficient interventions targeting males, ethnic minority, heterosexually infected and AIDS patients should be combined with immunologic monitoring, enhancement of coverage of HIV-testing and ART.
机译:为了评估中国与艾滋病相关的死亡率的模式和预测因素,并确定其与成人艾滋病毒/艾滋病(PLWHA)的相关性,我们对年龄至少在18岁以上的PLWHA进行了回顾性队列研究在1989年1月至2012年6月之间向国家数据库报告了后续行动。累积发病率函数用于计算艾滋病相关死亡率。格雷氏检验用于确定整个地层累积发生率的变化。精细和灰色模型用于衡量艾滋病相关死亡率累积发生的负担及其与潜在相关因素的关联强度。在研究期间,有375,629名患者中有107,634人死亡,其中54,759(50.87%)人死亡与艾滋病有关。诊断后一,二,五,十和十五岁的艾滋病相关死亡的累积死亡率分别为5.7%,8.2%,14.3%,22.9%和30.9%。在艾滋病毒/艾滋病感染者中,男性,少数民族和艾滋病患者死亡率高得多。此外,正在接受抗逆转录病毒疗法的同性恋传播和增加CD4检测频率与降低死亡率相关。为了降低艾滋病毒/艾滋病感染者的死亡率,针对男性,少数民族,异性感染和艾滋病患者的有效干预措施应与免疫学监测,艾滋病毒检测覆盖率和抗病毒治疗相结合。

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