Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations

摘要

Genome-wide association studies (GWASs) have revealed several genetic loci associated with HIV-1 outcome following infection (e.g., HLA-C at 6p21.33) in multi-ethnic populations with genetic heterogeneity and racial/ethnic differences among Caucasians, African-Americans, and Hispanics. To systematically investigate the inherited predisposition to modulate HIV-1 infection in Chinese populations, we performed GWASs in three ethnically diverse HIV-infected patients groups (i.e., HAN, YUN, and XIN, N?=?538). The reported loci at 6p21.33 was validated in HAN (e.g., rs9264942, P =?0.0018). An independent association signal (rs2442719, P =?7.85?×?10?7, HAN group) in the same region was observed. Imputation results suggest that haplotype HLA-B*13:02/C*06:02 , which can partially account for the GWAS signal, is associated with lower viral load in Han Chinese. Moreover, several novel loci were identified using GWAS approach including the top association signals at 6q13 ( KCNQ5 , rs947612, P =?2.15?×?10?6), 6p24.1 ( PHACTR1 , rs202072, P =?3.8?×?10?6), and 11q12.3 ( SCGB1D4 , rs11231017, P =?7.39?×?10?7) in HAN, YUN, and XIN groups, respectively. Our findings imply shared or specific mechanisms for host control of HIV-1 in ethnically diverse Chinese populations, which may shed new light on individualized HIV/AIDS therapy in China.