Expression of Extracellular Matrix Metalloproteinase Inducer (CD147) in Astrocytomas: A Histopathological and Immunohistochemical Study

摘要

Extracellular Matrix Metalloproteinase Inducer (EMMPRIN), also known as CD147, is a member of the adhesion molecules which play important roles in cellular function both in physiological and pathological processes. The main function of EMMPRIN is its role in tumour metastasis, angiogenesis, and chemoresistance.Aim: To investigate the immunohistochemical expression of EMMPRIN in cases of astrocytic CNS tumours.Materials and Methods: This retrospective study included a total of 60 archived, formalin fixed, paraffin embedded tissue blocks of 60 cases of astrocytic CNS tumours. The samples were immunohistochemically analysed for EMMPRIN expression.Results: A statistically significant correlation was detected between EMMPRIN expression and astrocytic CNS WHO tumour grade (p-value=0.035).Conclusion: EMMPRIN is a prognostic marker in astrocytic CNS tumours. In addition, it is implicated in tumour progression including invasion and migration.