Induction of Myocardial Infarction in Experimental Animals: A Review

摘要

Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientifc research.This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involvedand effcacy of treatment. Although, it is diffcult to create necrosis similar to those found in human heart, various large and smallanimals were used to create experimental model of MI. Each of these animals and method of selection offers various advantagesand disadvantages in relation to clinical studies. In the present review, we aim to highlight the different methods used to induce MIin experimental animals. These methods may be benefcial for academicians and researchers concerned with the treatment of MI.