Cells exhibit transient nuclear envelope ruptures during interphase, but the responsible biophysical processes remain unclear. In this issue, Hatch and Hetzer (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603053) show that actin fibers constrict the nucleus, causing chromatin protrusions and nuclear membrane ruptures at sites with nuclear lamina defects.
展开▼
机译:细胞在相间期表现出短暂的核膜破裂,但负责的生物物理过程仍不清楚。在此问题中,Hatch和Hetzer(2016. J. Cell Biol。)显示肌动蛋白纤维会收缩核,从而导致染色质突起和位点的核膜破裂核层缺损。
展开▼