Strong Correlation between Liver and Serum Levels of Hepatitis C Virus Core Antigen and RNA in Chronically Infected Patients

V. Descamps; A. Op de Beeck; C. Plassart; E. Brochot; C. Fran?ois; F. Helle; M. Adler; N. Bourgeois; D. Degré; G. Duverlie; S. Castelain

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Strong Correlation between Liver and Serum Levels of Hepatitis C Virus Core Antigen and RNA in Chronically Infected Patients

机译：慢性感染患者肝脏和血清丙型肝炎病毒核心抗原与RNA水平之间的强相关性

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HCV core antigen (Ag) and HCV RNA levels were evaluated in matched liver biopsy samples and sera from 22 patients with hepatitis C infection by using the quantitative Architect HCV Ag immunoassay and a real-time RT-qPCR assay, respectively. The data showed a strong correlation between liver and serum compartments of HCV Ag levels (r = 0.80) and HCV RNA levels (r = 0.87). In summary, the serum HCV Ag and RNA levels reflect the intrahepatic values.

机译：通过使用定量Architect HCV Ag免疫测定法和实时RT-qPCR测定法，分别在22名丙型肝炎感染患者的匹配的肝活检样本和血清中评估了HCV核心抗原（Ag）和HCV RNA水平。数据显示，HCV Ag水平（ r = 0.80）和HCV RNA水平（ r = 0.87）在肝脏和血清区室之间具有很强的相关性。总之，血清HCV Ag和RNA水平反映了肝内值。 展开▼

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《Journal of Clinical Microbiology》 |2012年第2期|共4页

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V. Descamps; A. Op de Beeck; C. Plassart; E. Brochot; C. Fran?ois; F. Helle; M. Adler; N. Bourgeois; D. Degré; G. Duverlie; S. Castelain;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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1. Negative Correlation of Serum Hepatitis B Surface Antigen and Hepatitis B e Antigen Levels with the Severity of Liver Inflammation in Treatment-naive Patients with Chronic Hepatitis B Virus Infection [J] . Lu Zhang, Lei-Ping Hu, Min Chang, 中华医学杂志（英文版） . 2017,第022期

机译：初治慢性乙型肝炎病毒感染患者血清乙型肝炎表面抗原和乙型肝炎e抗原水平与肝炎严重程度的负相关

2. PP-138 Correlations of plasma lipid level with serum hepatitis C virus RNA and liver histopathological steatosis in patients with chronic hepatitis C [J] . Y.-R.Li, W.Ling, F.-X.Chen, International journal of infectious diseases : . 2010,第Supplementa2期

机译：PP-138慢性丙型肝炎患者血浆脂质水平与血清丙型肝炎病毒RNA和肝组织病理性脂肪变性的关系

3. Effect of interferon-alpha and ribavirin therapy on serum GB virus C/hepatitis G virus (GBV-C/HGV) RNA levels in patients chronically infected with hepatitis C virus and GBV-C/HGV. [J] . Lau JY, Qian K, Detmer J, The Journal of Infectious Diseases . 1997,第2期

机译：干扰素-α和利巴韦林治疗对慢性感染丙型肝炎病毒和GBV-C / HGV的患者血清GB病毒C / G肝炎（GBV-C / HGV）RNA水平的影响。

4. HLA-C gene in Hepatitis C Virus infected Patients in Egypt, to estimate the relation between HLA-C gene and Interferon/Ribavirin as treatment for hepatitis C virus [C] . SHADEN MUAWIA HANAFY, AMAL AHMED ABBAS, SAFY KABEEL ALY MANSOUR International Conference on Cellular and Molecular Biology, Biophysics and Bioengineering . 2015

机译：HLA-C基因在丙型肝炎病毒中感染埃及患者，估计HLA-C基因和干扰素/利巴韦林与丙型肝炎病毒治疗的关系

5. Chimeric orthohepadnavirus core particles for oral delivery of vaccines: Part I. Transformation of tobacco plants with a gene encoding a c-terminus truncated hepatitis B virus core protein. Part II. Construction of a woodchuck hepatitis virus core protein-based universal epitope carrier and test expression in Escherichia coli. [D] . Callaghan, Maximilian W. 2001

机译：用于口服递送疫苗的嵌合正丙肝病毒核心颗粒：第一部分。用编码c末端截短的乙型肝炎病毒核心蛋白的基因转化烟草植物。第二部分基于土拨鼠肝炎病毒核心蛋白的通用表位载体的构建和大肠杆菌中的表达测试。

6. Strong Correlation between Liver and Serum Levels of Hepatitis C Virus Core Antigen and RNA in Chronically Infected Patients [O] . V. Descamps, A. Op de Beeck, C. Plassart, 2012

机译：慢性感染患者的丙型肝炎病毒核心抗原和RNA的肝脏和血清水平之间的强相关性

7. Strong Correlation between Liver and Serum Levels of Hepatitis C Virus Core Antigen and RNA in Chronically Infected Patients. [O] . Descamps, V, Op De Beeck, Anne, Plassart, C, 2012

机译：慢性感染患者的丙型肝炎病毒核心抗原和RNA的肝脏和血清水平之间有很强的相关性。

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7. sVAP-1与慢性丙型肝炎患者血清HCV-RNA水平及肝脏炎症的相关性研究 [A] . 彭莉莎 . 2014

1. 血清48-lncRNA作为肝脏慢性疾病诊断标记物的应用 [P] . 中国专利： CN107460234B . 2020.06.16

2. 血清48-lncRNA作为肝脏慢性疾病诊断标记物的应用 [P] . 中国专利： CN107460234A . 2017-12-12

3. isolated or recombinant polypeptide, conjugate, composition, isolated or recombinant polynucleotide, host cell, vector, methods for preparing the polypeptide, for preparing a conjugate, for inhibiting virus replication in virus-infected cells to reduce the number of copies of a virus in virus-infected cells, to reduce hcv rna level in serum of an hcv infected patient, to reduce hbv dna level in serum of an hbv infected patient, and to reduce hiv rna level in serum from an HIV-infected patient, and use of the polypeptide or conjugate [P] . 外国专利： BRPI0609809A2 . 2011-10-11

机译：分离的或重组的多肽，缀合物，组合物，分离的或重组的多核苷酸，宿主细胞，载体，用于制备多肽的方法，用于制备缀合物的方法，用于抑制病毒感染的细胞中的病毒复制以减少病毒中病毒的拷贝数感染的细胞，降低hcv感染患者血清中的hcv rna水平，降低hbv感染患者血清中的hbv dna水平，以及降低HIV感染患者血清中的hiv rna水平以及该多肽的用途或共轭

4. isolated or recombinant polypeptide, conjugate, composition, host cell, vector, methods for making a polypeptide, for making a conjugate, for reducing the copy number of a virus in virus-infected cells, for reducing the level of rna hcv, dna hbv and rna hiv in the serum of a patient infected with hcv, hbv and hiv, and use of the polypeptide, conjugate or composition [P] . 外国专利： BRPI0511196A . 2007-12-04

机译：分离的或重组的多肽，缀合物，组合物，宿主细胞，载体，制备多肽的方法，制备缀合物，减少病毒感染细胞中病毒的拷贝数，降低rna hcv，dna hbv和感染了hcv，hbv和hiv的患者血清中的rna hiv以及该多肽，缀合物或组合物的用途

5. Genetically engineered hepatitis c virus (hcv) nucleic acid clone, plasmid clone that houses a life-size hcv cdna, dna or rna transcribed from the full-length hcv cdna, transfected and in vitro infected host cell line with hcv, non-human animal infected with hcv, hcv viral particle, in vitro test system, hcv cell free, hcv vaccine and hcv test set and processes for identifying a cell line that is permissive and an animal that is permissive for hcv infection, to select hcv with adaptive mutations that allow higher levels of hcv replication in a permissive cell line, to infect an animal with hcv, to spread hcv in vitro, to transduce an animal susceptible to hcv infection with a heterologous gene, to produce hcv viral particles, hcv particle proteins and hcv antibodies, to separate agents capable of to modulate hcv replication, to prepare a hcv nucleic acid and to detect hcv antibodies in a biological sample from a patient. [P] . 外国专利： BR9808147A . 2000-03-28

机译：基因工程丙型肝炎病毒（hcv）核酸克隆，质粒克隆，其中包含从全长hcv cdna转录而来的真人大小的hcv cdna，dna或rna，并通过非人类动物的hcv转染和体外感染宿主细胞系被hcv感染，hcv病毒颗粒，体外测试系统，无hcv细胞，hcv疫苗和hcv测试仪的感染以及鉴定允许的细胞系和允许感染hvv的动物的过程，以选择具有以下适应性突变的hcv：允许在允许的细胞系中进行更高水平的hvv复制，以hvv感染动物，在体外传播hvv，用异源基因转导易感染hvv的动物，产生hvv病毒颗粒，hvv颗粒蛋白和hvv抗体分离能够调节hcv复制的试剂，制备hcv核酸并检测患者生物样品中的hcv抗体。

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Strong Correlation between Liver and Serum Levels of Hepatitis C Virus Core Antigen and RNA in Chronically Infected Patients

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